The Initiation of Renal-Replacement Therapy — Just-in-Time Delivery

The initiation of renal-replacement therapy--just-in-time delivery.

n engl j med 363;7 nejm.org august 12, 2010 678 structed on an advanced, entirely new technological platform, much of which comes from our new publishing partner, Atypon. Our new Web site is just one part of the revolution in information technology and delivery. Electronic delivery modes continue to proliferate. Social networks, intranets, mobile applications, tablet computers and e-readers, an...

Early initiation of renal replacement therapy in acute renal injury

Initiation of Renal-Replacement Therapy in the Intensive Care Unit.

INTRODUCTION One of the top research priorities in acute kidney injury is related to the timing of renal replacement therapy (RRT) initiation. The purpose was to develop an index that might serve as a standardized concept of timing of initiation of RRT. METHODS A previously described database was used. We applied a multivariable Cox regression model with backward selection to characterize par...

The optimal time of initiation of renal replacement therapy in acute kidney injury: A meta-analysis

BACKGROUND The impact on the timing of renal replacement therapy (RRT) initiation on clinical outcomes for patients with acute kidney injury (AKI) remains controversial. MATERIALS AND METHODS We searched the Cochrane Library, EMBASE, Global Health, MEDLINE, PubMed, the International Clinical Trials Registry Platform, and Web of Science. RESULTS We included 49 studies involving 9698 patients...

Too early initiation of renal replacement therapy may be harmful

In an observational multicenter study, Elseviers and colleagues report that renal replacement therapy (RRT) in acutely ill patients treated for acute kidney injury is an independent risk factor for death. This result may question the benefit of the current practice of early RRT initiation.